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WEDNESDAY, OCTOBER 6

13:00 Conference Registration

Overview

14:00 Chairperson’s Remarks

Penny Wilson, Ph.D., Lead Specialist, Detection and Identification of Infectious Agents, Technology Strategy Board, UK

Rosanna W. Peeling Ph.D

KEYNOTE PRESENTATION

14:05 Overview on POCT for Infectious Diseases: Its Promises and Challenges

Rosanna W. Peeling, Ph.D., Professor, Diagnostics Research, London School of Hygiene & Tropical Medicine, Faculty of Infectious & Tropical Diseases, Department of Clinical Research

Recent advances in real- time nucleic acid amplification and rapid detection technologies have led to the development of highly sensitive and specific diagnostic tests for infectious diseases that can potentially be used at the point of care. Results from POCTs can be used to guide clinical management decisions, including appropriate treatment. For diseases such as HIV, tuberculosis and sexually transmitted infections, the use of POCT would be of enormous public health benefit in that partner notification or contact tracing can be initiated without delay, thereby interrupting the chain of transmission and reducing the reservoir of infection in the community. However, substantial challenges remain in making POCTs that are affordable, simple, robust, and can be implemented at all levels of the health care system with their quality and performance assured.

Nick Crabb14:35 An Overview of the Diagnostics Related Programmes at NICE

Nick Crabb, Ph.D., Associate Director, Diagnostics Assessment Programme, National Institute for Health and Clinical Excellence, UK

Over the past year, NICE has been engaged in establishing two new programmes for the assessment of medtech products, including diagnostics. These initiatives build on experience of assessing medtech products within established NICE programmes and represent a major investment in bespoke capacity for medical devices and diagnostics. This presentation will provide an overview of the two medtech programmes with a focus on the assessment of diagnostic technologies.

David Brooks15:05 Recombinase Polymerase Amplification: Bringing Nucleic Acid Testing to Point of Care

David Brooks, Ph.D., M.B.A., Business Development Manager, TwistDx Ltd, UK

TwistDx has developed Recombinase Polymerase Amplification (RPA) an isothermal DNA amplification technology that uses recombinases and polymerases to pair oligonucleotides to specific sequences and synthesise copies of the target exponentially. RPA can detect single molecules of template in 10 minutes and is ideally suited to point of care nucleic acid testing.

15:35 Refreshment Break


 

Point-of-Care In Clinical Settings

16:30 Blood Glucose POCT in Intensive Care Unit Patients

Hans Günther Wahl, M.D., Ph.D., Director, Institute of Lab Medicine; Professor, University Hospital, Gießen and Marburg, Department of Clinical Chemistry and Molecular Diagnostics, Germany

Hyperglycaemia is commonly found in critically ill patients. Most hospitals by now use tight glycaemic control protocols for their patients in intensive care units to maintain normoglycaemia. In almost all cases, this will be done by POCT. This presentation will focus on glucose assay principles, specimen matrices, influences and interferences of glucose measurements and the numerous evaluation reports on point-of care glucose testing devices.

17:00 Implementing and Supporting POCT for Glucose, Cardiac Markers, Coagulation Parameters, Blood Gases and Ions in a Hospital Setting: Technical, Regulatory and Logistic Challenges

Viviane Van Hoof, M.D., Ph.D., Professor, Head of Department, Clinical Chemistry, University Hospital Antwerp, Belgium

In 2003, the central laboratory of the Antwerp University Hospital started the implementation of POCT for glucose, cardiac markers, ions, blood gases and coagulation parameters. In 2008, POCT accounted for 25% of the 9 million tests that were performed in the hospital. A POCT cell of lab technicians takes care of logistics and monitors quality control results that have to be compliant with those applied for central lab testing. We describe the technical, logistic and regulatory issues of POCT implementation and support.

18:30 – 21:00 BIOTECHNICA Night: Beer Hall, Full Dinner Reception, Live Band  


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