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Convergence of Technologies for Point-of-Care Diagnostics 

Technologies are evolving to transform diagnostic devices for rapid testing at the point-of-care. Portable devices are being engineered for use in a range of settings to perform robust assays for the diagnosis of disease that will improve patient management, and result in greater convenience and speed to answer. A discussion of the novel platforms and latest advances in sample prep, labeling, and detection will be covered. Find out how rapidly this area is growing and how it represents a viable solution to rising healthcare costs and expanded access to quality healthcare.

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TUESDAY, 11 OCTOBER

9:00 Conference Registration and Morning Coffee

 

Opening Session 

9:30 Chairperson’s Opening Remarks

Vanya A. Gant, M.D., Ph.D., Director, Center for Infectious Diseases & International Health, University College London School of Medicine
 

 

» KEYNOTE PRESENTATION 

9:35 Point-of-Care, Wearable and Mobile Biomedical Sensors

Christopher LoweChristopher R. Lowe, OBE, FREng, FInstP, FRSC, Director & Professor, Institute of Biotechnology, University of Cambridge

This lecture will review the current state of the art in diagnostic approaches which are applicable to discrete and real-time on-, at- or near-patient, i.e. wearable, point-of-care analysis of critical parameters for effective patient management and care.

 

10:05 Mobile Device for the Detection of MRSA and C. Difficile on Hospital Surfaces

Andrew Gover, COO, Vantix, Ltd.

Vantix Ltd. (formerly Universal Sensors) designs and manufactures Vantix™ biosensors that are sensitive, fast and versatile. It allows tests that traditionally take several hours of laboratory time to be performed in minutes and can be adapted for medical, veterinary and environmental applications. Through a Small Business Research Initiative (SBRI) competitive procurement process, Vantix is developing a portable device for the UK’s Department of Health to detect HCAI-related pathogens in hospital wards and care home settings.

10:35 Coffee Break - Networking with Sponsors

11:15 Industrialization & Economics of Smart Consumables in Life Sciences & Diagnostics

Ali Tinazli, Ph.D., Director, Business Development & Sales, BioSciences, Sony DADC Austria AG

Smart Consumables with microstructures / microfluidic features and functionalized surfaces are prerequisites for emerging applications in the Life Sciences and in-vitro Diagnostics (IVD) markets. The increasing complexity of such new products in those markets requires new manufacturing technologies. Sony DADC is now applying its excellence in customized mass manufacturing and its efficient processes to these highly sophisticated consumables in its new OEM business in a B2B format with leading, innovative companies in the biomedical field.

11:45 We Have the Technology: So Where Is the Roadmap to the Clinic?

Vanya A. Gant, M.D., Ph.D., Director, Center for Infectious Diseases & International Health, University College London School of Medicine

Diagnostic technologies now provide sublimely elegant solutions for detecting infectious agents. But technology alone can and will do nothing for better healthcare if not thoughtfully and appropriately integrated into clinical decision pathways. The speaker will illustrate these often poorly addressed if not completely overlooked issues of implementation with examples of failed technology for technology’s sake, and suggest some solutions.

        Sponsored by
mBioDiagnostics 
12:15 An Inexpensive, POC Readout for Multiplex Molecular Diagnostics
Christopher Myatt, Ph.D., Founder and CEO, MBio Diagnostics, Inc. 

12:45 Lunch for Purchase and Poster Viewing in Exhibit Hall 9

 

DECENTRALIZED HEALTHCARE SYSTEMS 

14:30 Chairperson’s Remarks

Craig Lehmann, Ph.D., CC (NRCC), ASCP, FACB, Dean, School of Health Technology and Management; Professor, Clinical Laboratory Sciences, Stony Brook University


» KEYNOTE PRESENTATION 

14:35 Decentralized Healthcare Systems and Applications

J.W. HofstraatJ.W. (Hans) Hofstraat, Ph.D., Vice President Philips Research, Healthcare Strategic Partnerships, Philips Research Laboratories

Challenges in the healthcare system are mounting. Aging and increasing numbers of patients suffering from chronic illness put an increasing challenge to healthcare cost and available care and cure workers. Health technology is developing at a fast pace within sectors like medical devices, pharmaceuticals, and biomed using new science such as genomics and nanotechnology.

15:05 Creating a Regional Health Information Exchange System from Tertiary to Home Health Care

Craig Lehmann, Ph.D., CC (NRCC), ASCP, FACB, Dean, School of Health Technology and Management; Professor, Clinical Laboratory Sciences, Stony Brook University

This presentation will provide the details of building a regional health information exchange (HIE) system from an academic tertiary care medical center. The HIE consists of the following partners: hospitals, nursing homes, assisted living communities, physicians, diagnostics (laboratory and radiology) and presently incorporating software for home care. There will be a description of Point of Care Diagnostic Technologies that are available and utilized in today’s home along with the economic benefits of such a HIE system.

15:35 Refreshment Break - Networking with Sponsors

 

Spotlight on New Technologies 

16:15 Sponsored Presentation (Opportunity Available)

16:45 Applying Nano Cantilever Technology to Detection of Organisms

Vincent C. Emery, Ph.D., Infection, School of Life and Medical Sciences (Royal Free Campus), University College London

Cantilever technology offers many opportunities for the direct detection of proteins such as antigens and antibodies against infectious organisms and potentially for the direct detection of organisms themselves. The latter is more challenging and I shall provide the latest update on our approaches to measure HIV particles using cantilever approaches based on developments made using novel antibodies and virus like particle systems optimized using SPR technology.

17:15 Diagnosing Tuberculosis within Two Hours: A Reality for TB POC

Lesley Scott, Ph.D., Professor, Molecular Medicine and Hematology, University of Witwatersrand

The TB and HIV epidemic in the developing world continues to pose enormous challenges to public health, including TB/HIV service integration. The Xpert MTB/RIF assay developed by Cepheid (Sunnyvale, CA) has recently been endorsed by the WHO as the initial method used to diagnose TB and replace smear microscopy. This molecular based POC assay has increased sensitivity, reduced turnaround time (2 hours) and immediate identification of rifampicin resistance, and therefore has potential to improve patient care and impact on global TB prevention.

17:45 Semiconductor Dx: From Sequencing to POC

Chris Toumazou, Ph.D., CEO and Founder, DNA Electronics Ltd.

DNA Electronics has developed a method for all-electronic detection of nucleic acid using standard semiconductor chips. This technology is key to recent developments in semiconductor sequencing by Ion Torrent and Roche 454 Life Sciences. However, the technology does not stop at sequencing. In this talk, we will also describe the semiconductor chips that do real-time amplification and detection of DNA.

18:15 Interactive Breakout Discussion Groups

TOPIC: Microfluidics: A Natural Fit for PoC Diagnostics Devices?

Moderator: Daniel Mark, Ph.D., Deputy Division Head, Lab-on-a-Chip, HSG-IMIT

  • Fields of applications: Which diagnostic scenarions benefit most from what Microfluidics has to offer?
  • The 4 Cs of clinical diagnostics: Costs, Convenience, Connectivity and Consolidation. Is current Microfluidics research sufficiently addressing those needs?
  • Macro to Micro interface: How can Microfluidic PoC devices handle samples with diagnostic relevance?

TOPIC: Incorporating Point-of-Care Technologies in the Clinical Setting

Moderator: Vanya A. Gant, M.D., Ph.D., Director, Center for Infectious Diseases & International Health, University College London School of Medicine

  • Technology leading the charge for change
  • Who pays for the test, and who benefits from the results?
  • Whose point-of-care instrument is it anyway?
  • Documenting results: clinical Governance issues
  • When and why do you need point of care testing? Defining the decision boundaries

TOPIC: Impact of POC on TB Prevention

Moderator: Lesley Scott, Ph.D., Professor, Molecular Medicine and Hematology, University of Witwatersrand

  • What is the definition of POC for TB?
  • Potentially the LAM and the Xpert MTB/RIF assays are identified as POC, therefore what is the best algorithm for use at POC, especially in light of smear negative disease?
  • What are the ways that national programs can monitor reduction in disease (prevention measures) once POC has been implemented?
  • How best to implement POC: contact finding, laboratory based testing, clinic based testing with follow up?

TOPIC: Integration of Technologies for Decentralized Diagnostics

Moderator: Luc Gervais, Ph.D., Swiss Federal Institute of Technology (EPFL)

  • What are the remaining challenges in integrating technologies for decentralized diagnostics?
  • What is limiting the adoption of a broader variety of decentralized diagnostics?
  • What are the key medical applications (niches) for which tests can be decentralized and patients can test themselves away from hospitals?
  • What are possible revenue models for companies developing next generation decentralized diagnostics (ex.: insurance reimbursement, consumer spending)?

19:15 BIOTECHNICA EVENT NIGHT – Keynote Presentation followed by Networking Reception. Live music and dancing.



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